The Red Sox, who improved to 6-0 against the Angels this season, are 12-6 following a 2-9 start. Boston has won 15 of its last 16 against the Angels.
Lester (4-1) allowed one run, six hits and one walk in seven innings, giving up Mark Trumbo's second-inning homer that put Los Angeles ahead. He struck out 10 or more for the 15th time in his career.
Dan Haren (4-2) allowed just two hits until the Red Sox got four in the sixth and two more in the seventh as they rallied for a 3-1 lead.
Gonzalez and Ortiz hit Boston's first consecutive homers this season to start the eighth inning. Three batters later, Marco Scutaro hit a two-run drive over the Green Monster.
Boston brought on closer Jonathan Papelbon with a 7-1 lead in the ninth. Papelbon gave up three straight hits, including Erick Aybar's RBI double, then allowed Trumbo's sacrifice fly before getting the final two outs.
Gonzalez's RBI single tied the score in the sixth and he scored on Jed Lowrie's single for a 2-1 lead. Jarrod Saltalamacchia hit an RBI double in the seventh, and Gonzalez led off the eighth with his first home run at Fenway since he was acquired by the Red Sox. That was Haren's final pitch of the night.
Ortiz then homered off Hisanori Takahashi.
Notes
Tuesday was the 8,000th game in Angels history. The first was a 7-2 win over Baltimore on April 11, 1961, when Ted Kluszewski homered twice and had five RBIs. CF Jacoby Ellsbury, who left Monday night's game with a bruised left knee contusion after he tripped over C Jeff Mathis, was back in the leadoff spot and extended his hitting streak to 12 games.